| Vinod Khanna | ... | Inspector Amar Khanna |
| Rishi Kapoor | ... | Akbar Ilhabadi/Raju |
| Amitabh Bachchan | ... | Anthony Gonzalves |
| Neetu Singh | ... | Dr. Salma Ali |
| Parveen Babi | ... | Jenny |
| Shabana Azmi | ... | Laxmi |
| Nirupa Roy | ... | Bharati |
| Pran | ... | Kishanlal |
| Jeevan | ... | Robert |
| Yusuf | ... | |
| Mukri | ... | Taiyyab Ali |
| Nasir Hussain | ... | Catholic Priest |
| Kamal Kapoor | ... | Superintendant Khanna |
| Hercules | ... | Zebisko |
| Shivraj | ... | Mr. Ilahabadi |
| Pratima Devi | ... | (as Protima Devi) |
| Moolchand | ... | (as Mulchand) |
| Master Bittoo | ... | Young Amar (as Master Bittu) |
| Master Ravi | ... | Young Anthony |
| Sabina | ... | Young Jenny (as Baby Sabina) |
| Master Tito | ... | Young Akbar |
| Helen | ... | Fake Daughter At Airport (Guest Appearance) |
| Nadira | ... | Stepmother (Guest Appearance) |
| Madhumati | ... | Bijli (Guest Appearance) |
| Ranjeet | ... | Ranjeet (Guest Appearance) |
Story:
This film set the trend of films based on the lost & found theme. A dozen odd films were made on this theme but no film succeeded the way Amar Akbar Anthony did.
Pran and Nirupa Roy get separated accidentally with their three kids. The kids are adopted by persons of three different religions. One is a Hindu, the second a Muslim and the third a Christian.
One boy grows up as Amar, the other as Akbar and the third as Anthony. Amar is a police officer, Akbar a tailor and Anthony, a good-for-nothing.
After a series of trials and tribulations, the lost and disintegrated family re-unites. This film had some very good comedy by Amitabh Bachchan and the three heroines, Shabana Azmi, Parveen Babi and Neetu Singh did good work as the soft and feminine influences on their beaus.